SYNTHESIS OF NEW HETEROCYCLIC SYSTEMS CONTAINING QUINOXALINE MOIETY

Ali El Janati, Youssef Kandri Rodi, K. Misbahi, Fouad Ouazzani Chahdi, A Zouitini, M Akhazzane, E. M. Essassi
2018
The synthesis of a new brick heterocyclic system of quinoxaline was developed by a cyclocondensation reaction starting from o-phenylenediamine derivatives. Thus 6-chloroquinoxaline-2,3(1H,4H)–dione was obtainedin excellent yield by condensation of 4-Chloro-o-phenylenediamine with oxalic acid at reflux in a hydrochloric acid solution. Thealkylationreactions werethen carried out and optimized by using monohalogenated agents under phase transfer catalysis conditions. The reaction studied lead to
more » ... n studied lead to the expected products in good yields and the structures of various obtained compounds are easilydetermined by the usual spectroscopic methods. This kind of products can show a potent pharmacological and therapeutic activitiesas given in the studies reported in the literature.
doi:10.48369/imist.prsm/jmch-v17i1.12212 fatcat:tvalycw6inabha6crav7jngb2e