2022-RA-805-ESGO Impact of surgery and chemotherapy timing on outcomes in older versus younger epithelial ovarian cancer patients: a nationwide Danish cohort study

Anne Weng Ekmann-Gade, Tine Henrichsen Schnack, Lene Seibæk, Mette Calundann Noer, Claus Høgdall
2022 Ovarian cancer   unpublished
based pre-and post-recurrence means and p-values for the difference in means. Results 269 of 486 enrolled patients had a PFS event resulting in a median PFS of 20.3 months. This analysis includes QoLevaluable 186 patients. Median age was 62.5 years (range 31 -90). The number of evaluable answers for each domain ranged between 166 and 172 before recurrence and 135 and 137 after recurrence. Global QoL decreased from 61.4 to 48.4 points (p<0.001) with the diagnosis of recurrence. The following
more » ... es showed a deterioration of at least 10 points: Social functioning (65.7-> 52.6), fatigue (44.5->55.8), appetite loss (22.5 -> 33.4), emotional functioning (65.2 -> 54.9), role functioning (56.5 -> 46.4); (all p<0.001). EQ-5D 3L visual analogue scale showed a deterioration from 66.4 to 55.0 (p<0.001). Conclusion The event of first relapse is associated with a significant and clinically relevant deterioration of global QoL including several subscales. Therefore, prolongation of PFS preserves QoL, which supports the role of PFS as meaningful primary endpoint in ovarian cancer trials.
doi:10.1136/ijgc-2022-esgo.564 fatcat:xfggn5426rd2bbttxcldxytcry