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Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection
2017
Cell Reports
Preserved Fulltext
Gro ¨schel et al. describe the virulenceneutral expression of the ESX-1 type VII secretion system of Mycobacterium marinum in the attenuated BCG vaccine. ESX-1-marinum enables recombinant BCG to rupture the phagosome and to induce cytosolic pattern recognition and dedicated innate immune signaling in mice, resulting in increased protection against tuberculosis.
doi:10.1016/j.celrep.2017.02.057
pmid:28297677
fatcat:izeiltlourcercm63jr3q43aci