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A Bayesian Network Model of Proteins' Association with Promyelocytic Leukemia (PML) Nuclear Bodies
Journal of Computational Biology
The modularity that nuclear organization brings has the potential to explain the function of aggregates of proteins and RNA. Promyelocytic leukemia nuclear bodies are implicated in important regulatory processes. To understand the complement of proteins associated with these intra-nuclear bodies, we construct a Bayesian network model that integrates sequence and protein-protein interaction data. The model predicts association with promyelocytic * To whom correspondence should be addressed 1doi:10.1089/cmb.2009.0140 pmid:20426694 fatcat:oyvos6ovvzb4jniubxsruflpxy