Conclusion

Johannes Lindner, Karsten Keller, Hermann Nirschl
2014
The separation of proteins by High Gradient Magnetic Filtration is a promising process for the purification of media. Its success depends on four different elements: the synthesis of coated particles with magnetic core, a selective functionalization which needs to be adapted to adsorb the target matter and exclude contamination, the separation devices which need to fit for the process in scale, budget and separation characteristics, and the process design. All of these elements need to fit
more » ... her and to be available at a reasonable price. Competing technologies comprise expanded and packed bed adsorption. The core advantage of magnetic separation is the fast kinetics, similar to expanded bed adsorption, but in a continuous process combined with an easier process control and a high flow rate. The recovery rate of the adsorbent achieves, depending on the particle magnetization, is more than 99.9 %. Particle Synthesis For particle synthesis, different methods were presented. The core may be produced, e.g., by laser pyrolysis, which is expensive but allows an exact adjustment of properties. The particle size and the chemical content can be influenced by this method. The size variation is very narrow, allowing the production of highly defined particles.
doi:10.5445/ir/1000047545 fatcat:xm3d5giznjcdrbyljxqojjbtja