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Mapping Aldehyde Dehydrogenase 1A1 Activity using an [18 F]Substrate-Based Approach
2019
Chemistry - A European Journal
Aldehyde dehydrogenases (ALDHs) catalyze the oxidation of aldehydes to carboxylic acids. Elevated ALDH expression in human cancers is linked to metastases and poor overall survival. Despite ALDH being a poor prognostic factor, the non-invasive assessment of ALDH activity in vivo has not been possible due to a lack of sensitive and translational imaging agents. Presented in this report are the synthesis and biological evaluation of ALDH1A1-selective chemical probes composed of an aromatic
doi:10.1002/chem.201805473
pmid:30521138
fatcat:vafdfp3pu5emtcxf5gczjkeuly