Pathophysiology, Classification and Comorbidities after Traumatic Spinal Cord Injury

James Guest, Nilanjana Datta, George Jimsheleishvili, David R. Gater
2022 Journal of Personalized Medicine  
The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing communication between the brain and the rest of the body, conveying complex sensory and motor information necessary for safety, movement, reflexes, and optimization of autonomic function. After a spinal cord injury (SCI), supraspinal influences on the spinal segmental control system and autonomic nervous system (ANS) are disrupted, leading to spastic paralysis, pain and dysesthesia, sympathetic blunting
more » ... d parasympathetic dominance resulting in cardiac dysrhythmias, systemic hypotension, bronchoconstriction, copious respiratory secretions and uncontrolled bowel, bladder, and sexual dysfunction. This article outlines the pathophysiology of traumatic SCI, current and emerging methods of classification, and its influence on sensory/motor function, and introduces the probable comorbidities associated with SCI that will be discussed in more detail in the accompanying manuscripts of this special issue.
doi:10.3390/jpm12071126 pmid:35887623 pmcid:PMC9323191 fatcat:dvliz4fwb5ckhibo4o3ze7fqli