Synthesis and antimicrobial evaluation of some novel malononitrile derivatives from N-phenylpyrrolidine-2, 5-diones under microwave irradiation

R. S. Dhivare, S. S. Rajput
2016 Zenodo  
The purpose of study was to synthesize the focused library of new malononitrile derivative of substituted Nphenylpyrrolidine-2,5-dione as potential new hybrid antifungal molecules. These hybrid molecules were synthesized in a coupling reaction of substituted N-phenylpyrrolidine-2, 5-dione with dicyanomethane using solvent-free ecofriendly microwave-assisted method. The 2, 5-diones were prepared by the reaction of succinic anhydride with substituted aryl amines in presence of benzene and acetyl
more » ... benzene and acetyl chloride. All the synthesized molecules were persisted and vetted for antimicrobial activities. Most of the molecules showed potential antifungal activity against Candida Albicans and Aspergillus niger.
doi:10.5281/zenodo.3909816 fatcat:6xingch765a7xefqb3b3zug5oy