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Dendrimer-Modified Gold Nanorods As A Platform For Combinational Gene Therapy And Photothermal Therapy of Tumors
[post]
2021
unpublished
Background: The exploitation of novel nanomaterials combining diagnostic and therapeutic functionalities within one single nanoplatform is challenging for tumor theranostics. Methods: We synthesized dendrimer-modified gold nanorods for combinational gene therapy and photothermal therapy (PTT) of colon cancer. Poly(amidoamine) dendrimers (PAMAM, G3) grafted gold nanorods were modified with GX1 peptide (a cyclic 7-mer peptide, CGNSNPKSC). The obtained Au NR@PAMAM-GX1 are performed as a gene
doi:10.21203/rs.3.rs-263824/v2
fatcat:yrkwmlymwjhixiq2glrtvtp4eu