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NBS1 and TRF1 Colocalize at Promyelocytic Leukemia Bodies during Late S/G2Phases in Immortalized Telomerase-negative Cells
Journal of Biological Chemistry
Nijmegen breakage syndrome, a chromosomal instability disorder, is characterized in part by cellular hypersensitivity to ionizing radiation. The NBS1 gene product, p95 (NBS1 or nibrin) forms a complex with Rad50 and Mre11. Cells deficient in the formation of this complex are defective in DNA double-strand break repair, cell cycle checkpoint control, and telomere length maintenance. How the NBS1 complex is involved in telomere length maintenance remains unclear. Here we show that the C-terminaldoi:10.1074/jbc.c000390200 pmid:10913111 fatcat:6gwgl2izyrhatiooscbwqa3foi