Zusammenfassung Contents Acknowledgments Collaboratory for Image Processing (HCI) of the University of Heidelberg under the supervision of Fred A. Hamprecht (University of Heidelberg) and Winfried Denk (Max-Planck-Institute for Medical Research) who established a stimulating and challenging research environment. I am most grateful for their guidance and advice. The HCI offers excellent research opportunities and training in the theory and applications of image analysis. The SBFSEM data analyzed

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... as part of this work was acquired by Kevin L. Briggman, Moritz Helmstaedter and Winfried Denk at the Max-Planck Institute for Medical Research. Working with this unique data is a pleasure. Several ideas presented in this thesis have been inspired by discussions with my supervisors and with Ullrich Köthe, Thorben Kröger, Moritz Helmstaedter and Kevin L. Briggman (Chapters 3, 4 and 6), Jörg Kappes and Bogdan Savchynskyy (Chapter 5). The implementation of these ideas in general purpose software was made possible by support from the student researchers