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Although the nerve auto graft still remains the clinical Gold standard in repairing nerve injury gaps, many advances have been achieved to guide regenerating axons across the lesion. Functional recovery after peripheral nerve lesion is depended upon accurate regeneration of axons to their original target tissues. To increase the prospects of axonal regeneration and functional recovery, researches have focused on designing " Nerve guidance channels" or NGCs.NGCs are either natural or syntheticdoaj:67c7b26d245241e081652f4aab5f3d65 fatcat:dylasguho5derncpoan54cab7i