Original Article An analytical description of distributions of HPV genotypes patients with cervical precancerous lesions and squamous cell carcinoma in Zhejiang and Jiangsu area

Xin Gu, Xiurong Long, Zhaoxia Yu, Sijun Xia, Jianxiang Geng
2017 Int J Clin Exp Med   unpublished
Objective: To investigate the distributions of human papillomavirus (HPV) infection type of women with cervical intraepithelial neoplasia (CIN) grade 2/3 and cervical squamous cell carcinoma (CSCC) in Zhejiang and Jiangsu Province, China. Methods: The research was based on the cross-sectional study. There were 219 cases of CIN2, 253 cases of CIN3 and 430 cases of CSCC from 14 local hospitals in Zhejiang and Jiangsu Province detected and genotyped by using HPV gene chip technology, and then
more » ... us subtypes of infection were analyzed and compared. Results: The HPV positive rates of CIN2, CIN3 and CSCC were 58.90%, 88.93%, and 90.23%, respectively, which in CIN3 and CSCC were significantly higher than that in CIN2 (P<0.001). The infection rate of high-risk HPV in CSCC was significantly higher than that in CIN2 and CIN3 (P<0.001), but the concurrent infection rate of high & low-risk HPV was only 0.70%, which was significantly lower than that in CIN2 and CIN3 (P<0.001). The most common type of infection in CSCC was HPV16, the sorts of HPV type in CIN3 and CIN2 was generally similar to that in CSCC, but the respective positive rates of the HPV type were not the same. Besides, the multiple infection rate in CSCC was significantly lower than that in CIN3 and CIN2 (P<0.001). Conclusion: HPV16, 18, 33, 58, 59, 31 and 52 are the most common types of CSCC in Zhejiang and Jiangsu Province. Further studies are needed to clarify the relationship between multiple infection and cervical cancer.
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