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Cerebellar granule neurons induce Cyclin D1 in an early stage of Huntington's disease
Although Huntington's disease (HD) is predominantly defined by selective vulnerability of striatal projection neurons, there is increasing evidence that cerebellar degeneration modulates clinical symptoms. However, little is known about cell type-specific responses of cerebellar neurons in HD. To dissect early disease mechanisms in the cerebellum and cerebrum, we analyzed translatomes of neuronal cell types from both regions in a new HD mouse model. For this, HdhQ200 knock-in mice weredoi:10.1101/2022.11.08.515613 fatcat:pwhyr4vmc5ecpjcnpsqb55i7f4