M147 Feasibility Of Delivering An Occupational Health Intervention Aimed At Improving Work Productivity, Among Working Copd Patients

K. Kalirai, P. Adab, R. Jordan, J. Ayres, S. Sadhra
2014 Thorax  
identify environmental and genetic factors associated with risk of vitamin D deficiency (25[OH]D concentration < 50 nmol/L). Results Mean serum 25(OH)D concentration was 45.4 nmol/L (SD 25.3); 171/278 (61.5%) participants were deficient. The following factors independently associated with increased risk of vitamin D deficiency: BMI >30 kg/m 2 (OR 1.87, p = 0.04) and blood draw during winter and spring seasons (OR 3.00, p < 0.01; OR 2.50, p < 0.01, respectively). The following factors
more » ... ly associated with reduced risk of deficiency: consumption of a vitamin D supplement, 100-400 IU/day (OR 0.42, p < 0.01); and a sunny holiday abroad no more than 2 months prior to blood draw (OR 0.27, p = 0.02). None of the 37 SNP investigated independently associated with vitamin D deficiency. Conclusions Vitamin D deficiency was highly prevalent among COPD patients in this study. Obesity and winter and spring sampling were risk factors for deficiency. Recent travel to a sunny country and consumption of vitamin D supplements were protective. Genetic variants in the vitamin D pathway that have previously been shown to associate with risk of vitamin D deficiency in healthy adult populations were not associated with deficiency in this patient group.
doi:10.1136/thoraxjnl-2014-206260.442 fatcat:rjvqnhe6vramjcbk2xri2afaf4