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Structure-based virtual screening (SBVS) has been widely applied in early-stage drug discovery. From a problem-centric perspective, we reviewed the recent advances and applications in SBVS with a special focus on docking-based virtual screening. We emphasized the researchers' practical efforts in real projects by understanding the ligand-target binding interactions as a premise. We also highlighted the recent progress in developing target-biased scoring functions by optimizing current genericdoi:10.1208/s12248-012-9322-0 pmid:22281989 pmcid:PMC3282008 fatcat:zc5f4ey6kzdulbwfyloavroaeq