Cancers of the kidney account for 2% of all the total human cancer. Squamous cell carcinoma (SCC) of renal pelvis is a rare neoplasm, accounting for only 0.5 to 0.8% of malignant renal tumors. In most cases, renal SCC is associated with chronic infections, chronic renal calculi, radiotherapy or any factor that can irritate the urothelium. We report a female patient aged 60 years diagnosed with Right Non-functioning Kidney with Nephrolithiasis with Suspicious Mass. Histopathological diagnosis

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... h Squamous Cell Carcinoma in Stage III with Staghorn Calculi. In long standing urolithiasis, possibility of concomitant harboring of malignancy needs to be taken into consideration.