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Plasminogen repairs abnormal pain perception through improving sensory function recovery and regeneration of peripheral small nerve fiber in db/db mice
Painful diabetic peripheral neuropathy (PDPN) is a devastating complication of diabetes and severely threatens the health of humankind. The plasminogen activator system and plasminogen (Plg) have multiple functional roles in tissue regeneration and extracellular matrix remodeling, which suggests that Plg may have a potentially pivotal role in anti-PDPN. In the present study, we explore whether an increased level of circulating Plg has positive effect on repairing abnormal pain perception indoi:10.1101/792325 fatcat:agehnndqmbbzriewrarkjbvykm