Quantitative analysis of tibial subchondral bone: Texture analysis outperforms conventional trabecular microarchitecture analysis

James W. MacKay, Philip J. Murray, Samantha B. L. Low, Bahman Kasmai, Glyn Johnson, Simon T. Donell, Andoni P. Toms
2015 Journal of Magnetic Resonance Imaging  
PURPOSE To compare two different methods of quantitative assessment of tibial subchondral bone in osteoarthritis (OA): statistical texture analysis (sTA) and trabecular microarchitecture analysis (tMA). METHODS Asymptomatic controls aged ͮͬ-ͯͬ (n=ͭͬ), patients aged Ͱͬ-ͱͬ with chronic knee pain but without established OA (n=ͭͬ) and patients aged ͱͱ-ʹͱ with advanced OA scheduled for knee replacement (n=ͭͬ) underwent knee MR imaging at ͯT with a ͯD gradient echo (GRE) sequence to allow sTA and
more » ... tMA and sTA features were calculated using ROI creation in the medial (MT) and lateral (LT) tibial subchondral bone. Features were compared between groups using one-way ANOVA. The two most discriminating tMA and sTA features were used to construct exploratory discriminant functions to assess the ability of the two methods to classify participants. RESULTS No tMA features were significantly different between groups at either MT or LT. ͭͳ/ͮͬ and ͭͭ/ͮͬ sTA features were significantly different between groups at the MT/LT respectively (p<ͬ.ͬͬͭ). Discriminant functions created using tMA features classified ͭͮ/ͯͬ participants correctly (Ͱͬ% accuracy, ͵ͱ% CI ͮͮ-ͱʹ%) based on MT data and ͵/ͯͬ correctly (ͯͬ%, ͭͰ-ͰͲ) based on
doi:10.1002/jmri.25088 pmid:26606692 fatcat:ozq3yfznybfedkd2npjkviyd5e