Involvement of dorsal hippocampal beta-1 noradrenergic receptors in memory retrieval of rats

Fathinia, Khajehpour, Moazedi Aa, Bemani-Lirgeshasi S
Central beta-noradrenergic system plays an important role in the learning and memory processes. Dorsal hippocampus also has an overlapped distribution of beta-noradrenergic receptors. The aim of this study was to evaluate the possible role of the dorsal hippocampal beta-1 noradrenergic receptors in memory retrieval using a passive avoidance learning task. Materials and Methods: This experimental study was performed on adult male Wistar rats (weight, 230±20gr). After anaesthetizing, the rats
more » ... izing, the rats were cannulated into dorsal hippocampus using the stereotaxic surgery. After one week, passive avoidance memory was studied in two phases: training and testing with a 24h interval. The step-through latency to enter dark compartment and the time spent in this compartment was recorded for the evaluation of memory. All animals received drugs or saline, as intra-dorsal hippocampal microinjection, 30 min before testing. Results: Pre-testing administration of dobutamine (1 μg/rat), a beta-1 noradrenergic receptor agonist, potentiated passive avoidance memory retrieval, while pre-testing injection of betaxolol (0.5μg/rat), a beta-1 noradrenergic receptor antagonist, inhibited passive avoidance memory retrieval. Also, the injection of ineffective and low doses of betaxolol (0.125 and 0.25 μg/rat) inhibited the effect of dobutamine on the memory retrieval. Conclusion: It seems that beta-1 noradrenergic receptors of the dorsal hippocampus may mediate memory retrieval in a passive avoidance learning model.