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Antibacterial activity of lupeol from the bark of Dehaasia cuneate (Lauraceae)

Andi Rifki Rosandy, School of Chemical Sciences and Food Technology, Faculty of Science and Technology Universiti Kebangsaan Malaysia, Sumail Sidik Ode Ishak, Noor Aziiraa Sabri, Wan Yaacob Wan Ahmad, Laode Muhammad Ramadhan Al Muqarrabun, University Center of Excellence for Nutraceuticals, Biosciences and Biotechnology Research Center, Bandung Institute of Technology, University Center of Excellence for Nutraceuticals, Biosciences and Biotechnology Research Center, Bandung Institute of Technology; School of Pharmacy, Bandung Institute of Technology, School of Chemical Sciences and Food Technology, Faculty of Science and Technology Universiti Kebangsaan Malaysia, School of Science UNSW Canberra at the Australian Defence Force Academy (ADFA)
2021 Current Research on Biosciences and Biotechnology  

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Dehaasia is a member Lauraceae. It is locally known as 'gajus hutan' or 'pekan'. A triterpenoid, lupeol was isolated from the bark of Dehaasia cuneate. The structure of the isolated compound was determined using spectroscopic methods, such as UV–vis, FT-IR, 1D and 2D NMR, and mass spectrometer. The isolated compound was tested against Gram-negative and positive bacteria using agar disc diffusion technique. The results showed that lupeol had a moderate inhibition zone value of 10.0±0.00 mm
more » ... t Gram-negative Serratia marcescens ATCC 14756 whereas low inhibition which is 7.0±0.00 mm against Escherichia coli ATCC 25922, Vibrio fluvialis ATCC 33809, Bacillus subtilis ATCC 6633, and Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300.
doi:10.5614/crbb.2021.2.2/bofy6724 fatcat:cwei7dy3tjgixn55zd7wntjepe
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Andi Rifki Rosandy, School of Chemical Sciences and Food Technology, Faculty of Science and Technology Universiti Kebangsaan Malaysia, Sumail Sidik Ode Ishak, Noor Aziiraa Sabri, Wan Yaacob Wan Ahmad, Laode Muhammad Ramadhan Al Muqarrabun, University Center of Excellence for Nutraceuticals, Biosciences and Biotechnology Research Center, Bandung Institute of Technology, University Center of Excellence for Nutraceuticals, Biosciences and Biotechnology Research Center, Bandung Institute of Technology; School of Pharmacy, Bandung Institute of Technology, School of Chemical Sciences and Food Technology, Faculty of Science and Technology Universiti Kebangsaan Malaysia, School of Science UNSW Canberra at the Australian Defence Force Academy (ADFA). "Antibacterial activity of lupeol from the bark of Dehaasia cuneate (Lauraceae)." Current Research on Biosciences and Biotechnology (2021) 145-148