A unique variant of hairy cell leukemia in Japan

Takashi MACHII, Yukihiro TOKUMINE, Ryoichi INOUE, Teruo KITANI
1990 Japanese Journal of Medicine  
Westudied 25 Japanese patients with hairy cell leukemia (HCL) and found a manner in which HCL can be divided into two subtypes. In each patient, hairy cells (HC) showed striking surface hairs and reacted with HC-specific antibodies ( aLeu-M5 and « HC-M). Twenty of the 25 patients had HC characterized by round nuclei with dense nuclear chromatin, weak tartrate-resistant acid phosphatase (TRAP) activity and the phenotype of low density surface immunoglobulin (SIg)+ , Tac~. In this group of 20
more » ... ents, the male to female ratio was low, and there was frequent leukocytosis. Onthe other hand, the remaining 5 patients showeda high male to female ratio and a normal or decreased leukocyte count. HChad folded nuclei, strong TRAPactivity and the phenotype of high density SIg+ , Tac+. The features of the latter patients are consistent with those of HCLin Western countries, while those of the former group appear to indicate a unique variant ofHCL.
doi:10.2169/internalmedicine1962.29.379 fatcat:4skghmirdvhjniun6t45gb5oku