Solvent-free microwave-assisted synthesis of aripiprazole

Jolanta Jaśkowska, Anna K. Drabczyk, Damian Kułaga, Przemysław Zaręba, Zbigniew Majka
2018 Current Chemistry Letters  
Aripiprazole is a widely used antipsychotic approved by the FDA (Food and Drug Administration) in 2002. Methods for preparation of aripiprazole mainly involve the use of expensive and toxic solvents, and the reaction time can be even several hours long. Our method allows to obtain aripiprazole with a yield of approximately 70-80% over just a few minutes using solvent-free conditions in the presence of PTC (Phase Transfer Catalysts) and microwave radiation.
doi:10.5267/j.ccl.2018.8.002 fatcat:c57sbwftyfdrxcqz5vi3thgrtq