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Intermolecular relationships of major surface proteins of Anaplasma marginale
Infection and Immunity
Immunization with Anaplasma marginale membranes containing major surface proteins (MSPs) induces protective immunity against clinical disease (N. Tebele, T. C. McGuire, and G. H. Palmer, Infect. Immun. 59:3199-3204, 1991). For use in design of a recombinant antigen subunit vaccine for A. marginak, intermolecular relationships of known A. marginale MSPs were analyzed. Under nonreducing conditions, MSP-2 and MSP-5 occur as multimers. A large (>300-kDa-molecular-mass), nonreduced protein complexdoi:10.1128/iai.62.7.2940-2946.1994 fatcat:zuayuhodvrbmrdktarxqda3o3a