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Progressive Brain Changes in Children and Adolescents With First-Episode Psychosis
Archives of General Psychiatry
Context: Progressive loss of brain gray matter (GM) has been reported in childhood-onset schizophrenia; however, it is uncertain whether these changes are shared by pediatric patients with different psychoses. Objective: To examine the progression of brain changes in first-episode early-onset psychosis and their relationship to diagnosis and prognosis at 2-year follow-up. Design: Prospective, multicenter, naturalistic, 2-year follow-up study. Setting: Six child and adolescent psychiatric unitsdoi:10.1001/archgenpsychiatry.2011.150 pmid:22213785 fatcat:x7kkdsnwu5dvbcoavwfencopry