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The invasion and metastasis of malignant tumors are the main factors affecting the prognosis of patients. Tumor parenchymal cells are significantly heterogeneous and their biological characteristics are very different. The tumor cells of the tumor invasive front (TIF) often play a decisive role in invasion and metastasis. It was found that the cells in this region may have more stem cell characteristics, more invasiveness and therapeutic resistance, which can better predict the progression ofdoaj:42a7b0bee3aa4f07993051a81b49cab8 fatcat:gzkvfbsrnbbfxjjxcouonm2d2y