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Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
2011
Nature Reviews Neuroscience
| The loss of control over drug intake that occurs in addiction was initially believed to result from disruption of subcortical reward circuits. However, imaging studies in addictive behaviours have identified a key involvement of the prefrontal cortex (PFC) both through its regulation of limbic reward regions and its involvement in higher-order executive function (for example, self-control, salience attribution and awareness). This Review focuses on functional neuroimaging studies conducted in
doi:10.1038/nrn3119
pmid:22011681
pmcid:PMC3462342
fatcat:vrfpkzqyuvc3tdwno5ahxgqqiu