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The effect of CH3HgOH on the thermal stability of calf thymus chromatin in Na2SO4 (10 mᴍ Na+, pH 6.8) has been studied spectrophotometrically by heat denaturation. From changes observed in the integral and differential melting profiles, gathered via absorbance measurements at 260 nm as a function of CH3HgOH concentration, it is concluded that methylmercury at low concentrations (1-10μᴍ), and prior to its denaturating the double-helix of the chromosomal DNA, interferes with the binding of DNA bydoi:10.1515/znc-1980-7-812 fatcat:7omqwcnzwvaktbedtowvcpell4