Formulation Development and Evaluation of Sustained Release Antidiabetic Tablet

Nitin Padole, Nilesh Mahajan, Fahim Kazi, Ujwala Mahajan, Ajay Pise
2016 Human Journals Research Article November   unpublished
Diabetes mellitus is chronic metabolic disorder caused by insufficient production of insulin. In type 1 diabetes mellitus there is failure in production of insulin as a result of destruction of the β cell of pancreas and in type 2 diabetes mellitus can be characterized by defect in both insulin action and insulin secretion and it is associated with elevated basal glucose production. Glipizide sustained release tablet were prepared using different hydrophilic polymer in different ratio that
more » ... ent ratio that retard the release of drug from tablet and for improvement of patient compliance. The sustained release tablets were prepared by direct compression method. The formulated tablet was subjected to test like thickness, friability, weight variation, hardness, drug content , in-vitro release study, similarity factor and stability study. Drug and polymer compatibility study was performed by FTIR. From all formulated batches optimized batch is selected in-vitro dissolution of formulated batch showed that F1 batch released the drug in control manner for 12 h. FTIR study showed that there was no interaction between drug and excipients. Similarity factor was calculated for selection of optimized batch. Cumulative release of optimized batch compared with marketed product Glynase Xl. Stability study was performed on both control sample and optimized batch at temperature 30 o C ± 2 o C up to month.