Objective: To assess the expression of Cyclin D1 in Mucoepidermoid Carcinoma (MEC) and its association with various histological grades. Study Design: Case series. Place and Duration of Study: AFIP Rawalpindi, from Nov 2017 to Apr 2018. Material and Methods: A total of 30 cases of MEC were included in this study. Paraffin embedded blocks of patients of both genders, diagnosed with salivary gland mucoepidermoid carcinoma were included as experimental samples while necrotic, scarce and autolysed

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... ases were not included. Tumor was graded as per the grading criteria of Auclair et al. Cyclin D1 was applied and the results were analyzed using chi-square test. Results: Of the 30 selected cases, 21 (70%) were male and 9 (30%) were female patients. According to histological grades, 14 (46.67%) comprised of low grade, 06 (20%) intermediate grade and 10 (33.34%) high grade tumors. Among these cases 6 (20%) were positive and 24 (80%) had altered results. In low grade MEC all 14 (0%) cases had negative results and none was positive. Among the 6 intermediate grade cases 3 (50%) showed positive and 3 (50%) showed altered expression and in high grade tumors 7 (70%) out of 10 had altered results and 3 (30%) showed positive results. A significant association (p-value=0.02) was seen between expression of Cyclin D1 and grades of MEC. Conclusion: A significant association was seen between Cyclin D1 expression and grades of MEC (p=0.02). Cyclin d1 showed an increase in expression with increase in grade of tumor. Hence it can serve as a potential marker for grading of mucoepidermoid carcinoma.