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C. elegans CEP-1/p53 and BEC-1 Are Involved in DNA Repair
2014
PLoS ONE
p53 is a transcription factor that regulates the response to cellular stress. Mammalian p53 functions as a tumor suppressor. The C. elegans p53, cep-1, regulates DNA-damage induced germline cell death by activating the transcription of egl-1 and ced-13. We used the C. elegans model to investigate how, in the whole animal, different forms of DNA damage can induce p53-dependent versus p53-independent cell death and DNA repair. DNA damage was induced by ultraviolet type C (UVC) radiation, or
doi:10.1371/journal.pone.0088828
pmid:24586407
pmcid:PMC3930633
fatcat:tqz5r6neq5gavhkjgs3bvevcum