Rapid and Reliable Measurement of Highly Elevated Blood Ammonia Concentrations in Children

Marinus H. De Keijzer, Bernadette S. Jakobs, Rob W. Brandts, Marc T. W. Hofs, Frans J. M. Trijbels, Jan A. M. Smeitink, Humboldt-Universität Zu Berlin, Humboldt-Universität Zu Berlin
Newborns and children may suffer from extremely high ammonia levels in their blood. We evaluated a fast, reliable micromethod, based on the Blood Ammonia Checker II (BAG II) in combination with the dilution with fresh whole blood. Comparison of the proposed method with an enzymatic method revealed a statistically significant correlation. We conclude that the dilution of patient's blood with fresh whole blood extends the measuring range of ammonia on the BAC II analyzer from 286 umol/l to about 700 umol/l.
doi:10.18452/13297 fatcat:sgsimsb3sneczpmki7rblyjd2m