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The equivalence between weak and strong purifying selection
[article]
2012
arXiv
pre-print
Weak purifying selection, acting on many linked mutations, may play a major role in shaping patterns of molecular evolution in natural populations. Yet efforts to infer these effects from DNA sequence data are limited by our incomplete understanding of weak selection on local genomic scales. Here, we demonstrate a natural symmetry between weak and strong selection, in which the effects of many weakly selected mutations on patterns of molecular evolution are equivalent to a smaller number of
arXiv:1210.4500v1
fatcat:npgqwhqt6zfbfem5rt2oibzuae