Total synthesis of plagiochin G and derivatives as potential cancer chemopreventive agents

Yue-Hu Wang, Yu Zhao, Hong-Xiang Lou, Susan L. Morris-Natschke, Rui-Juan Li, Xiao-Ming Yang, Qian Shi, Kuo-Hsiung Lee, Harukuni Tokuda
A new and efficient total synthesis has been developed to obtain plagiochin G (22), a macrocyclic bisbibenzyl, and four derivatives. The key 16-membered ring containing biphenyl ether and biaryl units was closed via an intramolecular SNAr reaction. All synthesized macrocyclic bisbibenzyls inhibited Epstein-Barr virus early antigen (EBVEA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and, thus, are potential cancer chemopreventive agents.
doi:10.17615/fx27-fx23 fatcat:yvhnnht4yvcljeyul6vnheleie