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In silicoand crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors having nanomolar potency
2018
Journal of Biological Chemistry
Heme cytotoxicity is minimized by a two-step catabolic reaction that generates biliverdin (BV) and bilirubin (BR) tetrapyrroles. The second step is regulated by two non-redundant biliverdin reductases (IX␣ (BLVRA) and IX (BLVRB)), which retain isomeric specificity and NAD(P)H-dependent redox coupling linked to BR's antioxidant function. Defective BLVRB enzymatic activity with antioxidant mishandling has been implicated in metabolic consequences of hematopoietic lineage fate and enhanced
doi:10.1074/jbc.ra118.001803
pmid:29487133
fatcat:qfpmu62uevedbicdc7g6qz3gri