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Splitting the Nucleus: What's Wrong with the Tripartite Ring Model?
Cold Spring Harbor Symposia on Quantitative Biology
The segregation of sister DNA molecules at mitosis involves their traction to opposite poles by microtubules attached to kinetochores. By creating tension required to stabilize kinetochore microtubules, sister chromatid cohesion has a key role in ensuring that sister kinetochores attach to microtubules with opposing polarity, a process known as biorientation. Cohesion is mediated by a cohesin complex whose Smc1, Smc3, and kleisin subunits form a tripartite ring thought to hold sister DNAsdoi:10.1101/sqb.2010.75.019 pmid:21209385 fatcat:janpcxg7b5fvbls3qdl7iaaqai