Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiators

Jens Preussner, Jiasheng Zhong, Mario Looso, Thomas Braun, Johnny Kim
2019 Molecular & Cellular Oncology  
How, if and in which cell types embryonic gene expression programs are elicited to induce tumor formation remains poorly understood. Through genomic analyses of regenerating, p53 deficient muscle stem cells we identified various oncogenomic amplifications, including but not limited to, the zygotic transcription factor Duxbl/DUXB to initiate tumorigenic transformation.
doi:10.1080/23723556.2019.1565469 pmid:31131298 pmcid:PMC6512926 fatcat:76ikc22cwvdhhmivtmbcb4x6gy