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Validation of a stroke model in rat compatible with rt-PA-induced thrombolysis: new hope for successful translation to the clinic
2020
Scientific Reports
The recent clinical trial (DAWN) suggests that recanalization treatment may be beneficial up to 24 h after stroke onset, thus re-opening avenues for development of new therapeutic strategies. Unfortunately, there is a continuous failure of drugs in clinical trials and one of the major reasons proposed for this translational roadblock is the animal models. Therefore, the purpose of this study was to validate a new thromboembolic stroke rat model that mimics the human pathology, and that can be
doi:10.1038/s41598-020-69081-0
pmid:32699371
fatcat:cdxxkscgsjavrlfzbujy7vkdx4