The Relationship between Initial Body Mass Index and Body Mass Index after One Year of Gonadotropin-Releasing Hormone Agonist Therapy in Idiopathic True Precocious Puberty Girls

Ju Young Yoon, Min Jae Kang, Se Young Kim, Ji Young Seo, Sei Won Yang, Young Ah Lee, Ji Eun Lee, Hye Rim Chung, Choong Ho Shin
2011 Journal of Korean Society of Pediatric Endocrinology  
The aim of this study is to evaluate the relationship between initial body mass index (BMI) and BMI after gonadotropin-releasing hormone agonist (GnRHa) treatment in idiopathic true precocious puberty girls. Methods: The subjects were 99 idiopathic true precocious puberty girls treated with GnRHa for more than 1 year. The patients were categorized into two groups according to initial BMI; normal weight group (BMI ˂ 85 percentile) and overweight/obesity group (BMI ≥ 85 percentile). We
more » ... d chronologic age (CA), bone age (BA), BA advancement (BA-CA), height (Ht), Ht-standard deviation score (Ht_zs), BMI, BMI_zs, predicted adult height (PAH), and PAH_zs before initiation of GnRHa treatment and 1 year later. Results: Baseline CA, BA, BA-CA, Ht_zs, and PAH showed no differences between normal weight group and overweight/obesity group. BMI_zs increased only in normal weight group, and BMI_zs was negatively correlated ∆ with initial BMI_zs (r = -0.501, P ˂ 0.001). PAH_zs increased less in normal weight group ( PAH_zs ∆ = 0.30) than in overweight/obesity group ( PAH_zs ∆ = 0.66) (P = 0.02), but there was no correlation between initial BMI_zs and PAH_zs. BA-CA and Ht_zs were not different between two groups either. Comparing patients with increased ∆ ∆ ∆ BMI_zs with those whose BMI_zs decreased or remained the same, there were no differences in BA-CA, Ht_zs, ∆ ∆ and PAH_zs. On multiple regression analysis, BMI_zs was negatively correlated with initial BMI_zs, and it showed ∆ ∆ no correlation with CA, BA, BA-CA, height, and dose of GnRHa. Conclusion: BMI_zs increased after 1yr of GnRHa treatment in idiopathic true precocious puberty girls whose initial BMI_zs was normal, and its increment was negatively correlated with initial BMI_zs.
doi:10.6065/jkspe.2011.16.3.165 fatcat:ugdwkahzprebfhrxmxafuz5wy4