Diabetes mellitus is one of the most critical health issues in the health care system. Patients with Diabetes are subject to various complications. Diabetic foot infection is one of most incapacitating kinds of human infection. Due to growing antimicrobial and antibiotic resistance, existing medications have undesirable side effects and inadequate healing mechanisms. Probiotics are either a single organism or combination of organisms capable of boosting the body's immune system, promoting

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... nflammatory action, and enhancing the wound healing process at the site of an infection. Therefore, it is a revolutionary strategy to use probiotics to eradicate harmful microorganisms and enhance wound healing. Hence the present study was performed to compare the conventional method and local application of probiotics to treat Diabetic foot ulcer. In present study average age of patients in both group were found almost similar 58.58 years in control group and 57.3 years in probiotic group. The diabetic foot wound size of all patients in both groups were evaluated and it was found that mean wound size in both group were almost same. During the study it was found that there was no significant difference in mean wound bed score between two groups on day 1(Control:8.12; Probiotic: 8.24), whereas a significant difference observed on day 7(Control: 10.36; Probiotic; 11.14) and day 14 (Control:12.78; Probiotic:13.56). An increase was seen in mean wound bed score in both groups from day 1 to day 14 but it was observed more in Probiotic group. Present study concludes that probiotics can be safely utilized in therapy of infected diabetic wounds. The probiotic when used along with conventional therapy could results in the hastening the wound healing process as evidenced by significant difference in the day 7 and 14 wound bed scores. Although more studies are needed in this field to give better evidence for support of probiotic use.