"FORMULATIONS AND EVALUATIONS OF METFORMIN MICROSPHERES BY IONOTROPIC GELATION TECHNIQUE"

Namrata N. Patil
2017 World Journal of Pharmacy and Pharmaceutical Sciences  
The aim of the present work was formulation and evaluation of Metformin microspheres by ionotropic gelation method using sodium alginate, HPMC, Carbopol as polymer and Cacl2 as cross-linking agent. Sodium alginate is biodegradable natural polymer with a great potential for pharmaceutical applications due to its good biocompatibility and non-toxicity. Metformin hydrochloride microspheres have good properties. High drug incorporation in microspheres could be achieved by ionotropic gelation method
more » ... without using any toxic chemicals which causes undesirable effects.The microspheres are evaluated for Percentage yield, Entrapment efficiency, Micromimetics property, In-vitro Drug release etc. extensive in the in-vitro method it was observed that more than 102% of drug is release by 11-12 hr itself.in this formulation, drug release is more sustained upto 12hr. The Percentage entrapment efficiency is 102%. The Percentage Yields of microspheres were found to be 96%. Also the ionotropic gelation can be carried out under very mild conditions using simple equipments. The control of various manufacturing parameters plays a very important role in obtaining microspheres of good sphericity, high yield and high drug encapsulation.
doi:10.20959/wjpps20175-9190 fatcat:fmyg4e677nf7blfiqaztjscn3q