The aim of the present work was formulation and evaluation of Metformin microspheres by ionotropic gelation method using sodium alginate, HPMC, Carbopol as polymer and Cacl2 as cross-linking agent. Sodium alginate is biodegradable natural polymer with a great potential for pharmaceutical applications due to its good biocompatibility and non-toxicity. Metformin hydrochloride microspheres have good properties. High drug incorporation in microspheres could be achieved by ionotropic gelation method

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... without using any toxic chemicals which causes undesirable effects.The microspheres are evaluated for Percentage yield, Entrapment efficiency, Micromimetics property, In-vitro Drug release etc. extensive in the in-vitro method it was observed that more than 102% of drug is release by 11-12 hr itself.in this formulation, drug release is more sustained upto 12hr. The Percentage entrapment efficiency is 102%. The Percentage Yields of microspheres were found to be 96%. Also the ionotropic gelation can be carried out under very mild conditions using simple equipments. The control of various manufacturing parameters plays a very important role in obtaining microspheres of good sphericity, high yield and high drug encapsulation.