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The aim of the present work was formulation and evaluation of Metformin microspheres by ionotropic gelation method using sodium alginate, HPMC, Carbopol as polymer and Cacl2 as cross-linking agent. Sodium alginate is biodegradable natural polymer with a great potential for pharmaceutical applications due to its good biocompatibility and non-toxicity. Metformin hydrochloride microspheres have good properties. High drug incorporation in microspheres could be achieved by ionotropic gelation methoddoi:10.20959/wjpps20175-9190 fatcat:fmyg4e677nf7blfiqaztjscn3q