l‐Carnitine in dialysis, more than a commercial affair

P. Rodríguez‐Benítez, R. Pérez‐García, J. Arenas, F. Valderrábano
2000 Nephrology, Dialysis and Transplantation  
Stimulation of TGF-beta type II receptor gene expression in high with respect to the general population on dialysis. This mouse mesangial cells by high glucose and in diabetic kidney. is probably due to several factors: a high number of malnour- Am J Physiol (in press) ished patients, a large proportion of whom are on high 2. Mogyoró si A, Ziyadeh FN. GLUT1 and TGF-b: the link between efficiency dialysis with highly permeable membranes and hyperglycemia and diabetic nephropathy. Nephrol Dial
more » ... nsplant because most of the patients had been dialysed for many 1999; 14: 2827-2829 years. 3. DCCT. The effect of intensive treatment of diabetes on the It has been observed that tissue carnitine deficiency is development and progression of long-term complications in directly correlated to low levels of free serum carnitine and insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 1993; high levels of acylcarnitines. We have looked for clinical and 329: 977-986 biochemical parameters related to a low free carnitine plasma 4. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of level. The latter is directly related to plasma albumin and angiotensin-converting-enzyme inhibition on diabetic nephro-PCR, and inversely to Kt/V. Plasma albumin depends mainly pathy. The Collaborative Study Group. N Engl J Med 1993; 329: on hepatic protein synthesis and may be diminished because 1456-1462 of liver malfunction, inflammation and lack of amino acid 5. Ravid M, Savin H, Jutrin I et al. Long-term effect of ACE precursors in the diet, among other causes. PCR depends on inhibition on development of nephropathy in diabetes mellitus protein ingestion. In case it is low, PCR is diminished. type II. Kidney Int 1994; 45 [Suppl ]: S161-S164 Endogenous carnitine synthesis may also be low due to the 6. Mogyoró si A, Sonkodi S. AT1 receptor antagonists: a challenge for ACE inhibitors in diabetic nephropathy. Diabetes Metab Res lack of its precursors in low protein diets. Therefore serum Rev 1999; 15: 55-58
doi:10.1093/ndt/15.9.1477 pmid:10978418 fatcat:7vmoennhyjfangl6isd4sbhqnu