Non-invasive reservoir pressure parameters : measurement and clinical relevance

X Peng
2019
High blood pressure (BP) is the single greatest risk factor for death from cardiovascular diseases (CVD). High BP is conventionally defined by the systolic BP and diastolic BP, which are the peak and nadir points on the BP waveform, but cannot comprehensively represent systemic arterial haemodynamics. The reservoir-excess pressure model, which was proposed to analyse the BP waveform, provides potentially new information regarding arterial haemodynamics. The reservoir-excess pressure model
more » ... ressure model interprets the BP waveform into a reservoir pressure (RP), which is related to the buffering capacity of elastic arteries, and into an excess pressure (XSP), which is ascribed to wave propagation in the arterial system. Furthermore, reservoir pressure parameters (e.g. RP, XSP and the associated systolic rate constant) have been shown to predict cardiovascular events independent of standard BP and other conventional cardiovascular risk factors. However, non-invasive measurement of reservoir pressure parameters is technically challenging, which limits the widespread application of reservoir pressure parameters. Thus, the overall aims of this research programme were to determine whether reservoir pressure parameters could be non-invasively measured in the human upper arm using an oscillometric cuff device, and further to determine whether cuff device-measured reservoir pressure parameters were clinically relevant – this was assessed by association with cardiovascular risk markers. In chapter 2, the change in reservoir pressure parameters from the aorta to the brachial and radial arteries was invasively investigated in 51 participants undergoing coronary angiography. A relatively constant RP and an amplified XSP were observed from the aorta to the brachial and radial arteries. These observations provide a new understanding on arterial reservoir pressure parameters and large artery BP physiology. In chapter 3, the performance of an oscillometric cuff device for measuring the central BP was investigated in 182 people with treated hype [...]
doi:10.25959/100.00031752 fatcat:apbq6wru7bh6ze5gqadluxnbfu