Job stress is one of the occupational hazards in the modern era. The National Institute for Occupational Safety and Health introduced the nursing job as a top 40 stressful jobs. In this job, multiple training techniques are considered to reduce stress and stress factors. This study was conducted to response the question "Is the use of health education programs can be effective in reducing job stress?" Material and Method: Electronic search was done using key words in Persian and English

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... and English database (Medical Sciences, Iran Medex), Scientific Information Database (SID), Bio Med Central, Pub Med, Science Direct) and were found 3,412 paper totally. Articles examined based on defined criteria and 9 qualified articles were discussed systematically. Result: Among the reviewed studies, educational interventions in 7 studies were without, and 2 studies were with the use of health education models. The results of studies indicated significant effect of educational interventions on reducing job stress and using health education models in interventions had a greater effect on reducing job stress. Conclusion: The results highlights the importance of educational interventions based on health education models to reduce occupational stress among nurses.