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Histone Modifying Enzymes as Targets for Therapeutic Intervention in Oesophageal Adenocarcinoma
Oesophageal adenocarcinoma (OAC) has a dismal prognosis, where curable disease occurs in less than 40% of patients, and many of those with incurable disease survive for less than a year from diagnosis. Despite the widespread use of systematic chemotherapy in OAC treatment, many patients receive no benefit. New treatments are urgently needed for OAC patients. There is an emerging interest in epigenetic regulators in cancer pathogenesis, which are now translating into novel cancer therapeuticdoi:10.3390/cancers13164084 fatcat:kvigjryoj5c5bndhw6h65qb4ua