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Innate immunity gene Nod2 protects mice from orthotopic breast cancer
Nod2 is involved in innate immunity to bacteria, regulation of metabolism, and sensitivity to cancer. Nod2 polymorphism is associated with breast cancer, but the role of Nod2 in the development and progression of breast cancer is unknown. Here, we tested the hypothesis that Nod2 protects mice from breast cancer using the 4T1 orthotopic model of mammary tumorigenesis. We demonstrate that Nod2−/− mice have higher incidence and larger tumors than WT mice. Detailed analysis of the tumordoi:10.21203/rs.3.rs-1852004/v2 fatcat:6zdj22a6r5ezfhe2ktu4oqn3am