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OR21-05 Primary Thyroid Lymphoma Developing from a Background of Lymphocytic Thyroiditis: First Report in Mice
Journal of the Endocrine Society
Primary thyroid lymphoma is rare, accounting for less than 5% of all thyroid malignancies. It typically develops in patients with Hashimoto thyroiditis who have approximately a 70 fold higher risk than other patients. The mechanisms underlying the development of thyroid lymphoma remain unclear, and no mouse model has been described. For our studies of papillary thyroid cancer and lymphocytic thyroiditis, we crossed TPO-Cre-ER transgenic mice and hBRAFV600E knock-in mice onto the NOD.H2h4doi:10.1210/jendso/bvaa046.1326 fatcat:nyvfpd6enrcjld24cos6spzdsq