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Journal of Virology
Epstein-Barr virus (EBV) is a highly efficient acute transforming agent in human cells, provided that the intact virus is used. To investigate the ability of viral DNA alone to transform cells, we introduced the EBV genome into human lymphocytes. After microinjection of EBV DNA into neonatal B lymphocytes, we established a cell line that in early passages contained multiple viral fragments. This cell line retained sequences from the short, unique (U,) region of the EBV genome and sequences fromdoi:10.1128/jvi.61.5.1552-1558.1987 fatcat:crprv72u2fb3rdxyotjqfggwae