Relationship Between Biodosimetric Parameters and Treatment Volumes in Three Types of Prostate Radiotherapy [post]

Zsuzsa S. Kocsis, Tibor Major, Csilla Pesznyák, Dalma Mihály, Gábor Stelczer, Márta Kun-Gazda, Gyöngyi Farkas, Gábor Székely, Péter Ágoston, Kliton Jorgo, László Gesztesi, Csaba Polgár (+1 others)
2021 unpublished
Brachytherapy (BT) and external beam radiotherapy (EBRT) apply different dose rates, overall treatment times, energies, fractionation. However, the overall impact of these variables is neglected on the biological dose of blood. As the size of the irradiated volume also influences the biological effect, we studied chromosome aberrations (CAs) as biodosimetric parameters, and explored the relationship of isodose surface volumes (ISVs: V1%, V1Gy, V10%, V10Gy, V50Gy, V100%, V150%) and CAs in case
more » ... ) and CAs in case of both irradiation modalities. We performed extended dicentrics assay of lymphocytes from 102 prostate radiotherapy patients three-monthly for a year. Aberration frequency was the highest after EBRT treatment. It increased after the therapy and did not decrease significantly during the first follow-up year. We showed that various types of CAs nine months after LDR BT, three months after HDR BT in a long time-range (even till one year) after EBRT positively correlated with ISVs. Regression analysis confirmed these relationships in case of HDR BT and EBRT. The observed differences in the time points and aberration types are discussed.The ISVs irradiated by EBRT showed stronger correlation and regression relationships with CAs than the ISVs of brachytherapy in spite of the fractionation.
doi:10.21203/rs.3.rs-418759/v1 fatcat:56phbl5ppnel3j6uspzykklfhe