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Atomic resolution structure determinations of proteins by X-ray crystallography are formidable multidisciplinary undertakings, requiring proteinconstruct design, expression and purification, crystallization trials, phase determination, and model building. Modern mass spectrometric methods can greatly facilitate these obligate tasks. Thus, mass spectrometry can be used to verify that the desired protein construct has been correctly expressed, to define compact domains in the target protein, todoi:10.1146/annurev.biophys.30.1.67 pmid:11340052 fatcat:qmjovrcgczbejmzgndzictzfl4